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Impact of biliary complications in right lobe living donor liver transplantation.

机译:胆道并发症对右叶活体供肝移植的影响。

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摘要

Biliary reconstruction is one of the most challenging parts of right lobe living donor liver transplantation (RL LDLT), and biliary complications have been reported as the first source of surgical complications of this procedure. We reviewed biliary reconstruction and complications in 27 consecutive RL LDLTs. We compared the first 14 procedures (group 1) to the last 13 (group 2). Seven patients (25.9\%) experienced a biliary complication (five leaks and two strictures). The incidence of biliary complications was 11.1\% in RL grafts with a single duct and 55.5\% in graft presenting multiple bile ducts (P = 0.03). Four of the 18 patients with a duct-to-duct reconstruction (22.2\%) and three of the 11 patients with a Roux-en-Y reconstruction (27.3\%) developed a biliary complication (P = ns). The incidence of biliary complications significantly decreased from 42.9\% (n = 6) in the first group to 7.6\% (n = 1) in the second group (P = 0.05). The overall 1-year graft and patient survival were 57.1\% and 64.3\% in group 1 versus 100.0\% and 100\% in group 2 (P = 0.01; P = 0.006). Biliary complications remain one of the most important technical complications affecting RL LDLT. Nevertheless, attention and surgical refinement can lead to a significant reduction of the biliary complication rate, improving graft and patient survival.
机译:胆道重建术是右叶活体供体肝移植(RL LDLT)最具挑战性的部分之一,据报道胆道并发症是该手术手术并发症的首要来源。我们回顾了连续27例RL LDLT中的胆道重建和并发症。我们比较了前14个程序(第1组)和后13个程序(第2组)。 7名患者(占25.9%)经历了胆道并发症(5次漏泄和2次狭窄)。单管的RL移植组胆管并发症发生率为11.1%,而多管移植的胆管并发症发生率为55.5%(P = 0.03)。 18例行导管重建术的患者中有4例(22.2%),11例进行Roux-en-Y术的患者中3例(27.3%)发生了胆道并发症(P = ns)。胆道并发症的发生率从第一组的42.9%(n = 6)显着降低到第二组的7.6%(n = 1)(P = 0.05)。第1组的总体1年移植物和患者存活率为57.1%和64.3%,而第2组为100.0%和100%(P = 0.01; P = 0.006)。胆道并发症仍然是影响RL LDLT的最重要的技术并发症之一。尽管如此,注意和外科手术的改进可以导致胆道并发症的发生率显着降低,从而改善移植物和患者的生存率。

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